Gene

hars

ID

ZDB-GENE-040912-152

Name

histidyl-tRNA synthetase

Symbol

hars Nomenclature History

Previous Names

im:7136719
zgc:92215 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have histidine-tRNA ligase activity and identical protein binding activity. Involved in regulation of vasculature development and sprouting angiogenesis. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to several human genes including HARS1 (histidyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136719 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hars Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease, axonal type 2W	Alliance	Charcot-Marie-Tooth disease, axonal, type 2W	616625
Perrault syndrome	Alliance	Perrault syndrome 2	614926
Usher syndrome type 3B	Alliance	Usher syndrome type 3B	614504

Associated With hars Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000738	WHEP-TRS domain
Domain	IPR004154	Anticodon-binding
Domain	IPR006195	Aminoacyl-tRNA synthetase, class II
Domain	IPR033656	Histidyl-anticodon-binding
Domain	IPR041715	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain
Family	IPR004516	Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
Family	IPR015807	Histidine-tRNA ligase
Homologous_superfamily	IPR009068	uS15/NS1, RNA-binding domain superfamily
Homologous_superfamily	IPR036621	Anticodon-binding domain superfamily
Homologous_superfamily	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)