Gene

pfkma

ID

ZDB-GENE-040912-135

Name

phosphofructokinase, muscle a

Symbol

pfkma Nomenclature History

Previous Names

pfkm (1)
wu:fc58g11
zgc:92344

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have several functions, including 6-phosphofructokinase activity; adenyl ribonucleotide binding activity; and fructose-6-phosphate binding activity. Predicted to be involved in several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and protein homotetramerization. Predicted to localize to 6-phosphofructokinase complex and membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Is expressed in male organism; musculature system; myotome; and pectoral fin musculature. Orthologous to human PFKM (phosphofructokinase, muscle).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151834 (6 images)
IMAGE:7147892 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfkma Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
glycogen storage disease VII	Alliance	Glycogen storage disease VII	232800

Associated With pfkma Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR015912	Phosphofructokinase, conserved site
Domain	IPR000023	Phosphofructokinase domain
Family	IPR009161	ATP-dependent 6-phosphofructokinase, eukaryotic-type
Family	IPR022953	ATP-dependent 6-phosphofructokinase
Family	IPR041914	ATP-dependent 6-phosphofructokinase, vertebrate-type
Homologous_superfamily	IPR035966	Phosphofructokinase superfamily