Gene

kif2a

ID

ZDB-GENE-040912-111

Name

kinesin family member 2a

Symbol

kif2a Nomenclature History

Previous Names

fj55b02
wu:fj55b02
zgc:103670 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including habituation; swimming behavior; and transmission of nerve impulse. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in head; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103670 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Partoens et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif2a Human Ortholog

No data available

Associated With kif2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Domain	IPR054473	Kinesin-like protein KIF2A-like, N-terminal
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Kinesin-like protein	Kinesin-like protein KIF2A-like, N-terminal	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1RAK1 InterPro	719
UniProtKB:A0A8M1N222 InterPro	719
UniProtKB:A0A8M2BEB6 InterPro	747

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kif2a-201 (1) Ensembl	Ensembl		3,712 nt	Select Tool ZFIN BLAST
mRNA	kif2a-202 (1) Ensembl	Ensembl		441 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations