Gene
suclg1
- ID
- ZDB-GENE-040912-101
- Name
- succinate-CoA ligase GDP/ADP-forming subunit alph
- Symbol
- suclg1 Nomenclature History
- Previous Names
-
- SUCLGa (1)
- zgc:103729
- zgc:92738
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908198 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-suclg1 | China Zebrafish Resource Center (CZRC) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 9 | Alliance | Mitochondrial DNA depletion syndrome 9 (encephalomyopathic type with methylmalonic aciduria) | 245400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR017440 | ATP-citrate lyase/succinyl-CoA ligase, active site |
| Conserved_site | IPR033847 | ATP-citrate lyase/succinyl-CoA ligase, conserved site |
| Domain | IPR003781 | CoA-binding |
| Domain | IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain |
| Family | IPR005810 | Succinyl-CoA ligase, alpha subunit |
| Homologous_superfamily | IPR016102 | Succinyl-CoA synthetase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-citrate lyase/succinyl-CoA ligase, active site | ATP-citrate lyase/succinyl-CoA ligase, conserved site | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | CoA-binding | NAD(P)-binding domain superfamily | Succinyl-CoA ligase, alpha subunit | Succinyl-CoA synthetase-like |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I58 | InterPro | 324 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
suclg1-201
(1)
|
Ensembl | 1,378 nt | ||
| ncRNA |
suclg1-002
(1)
|
Ensembl | 803 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-131K10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-162B23 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6908198 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92738 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103729 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191301 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002577 (1) | 1364 nt | ||
| Genomic | GenBank:CR388005 (1) | 197480 nt | ||
| Polypeptide | UniProtKB:Q66I58 (1) | 324 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SUCLG1 | 2 | Amino acid sequence comparison (1) |
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, C.Y., Lee, H.C., Fu, C.Y., Ding, Y.Y., Chen, J.S., Lee, M.H., Huang, W.J., and Tsai, H.J. (2013) miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos. Nature communications. 4:2829
- Wang, Y.W., Wei, C.Y., Dai, H.P., Zhu, Z.Y., and Sun, Y.H. (2013) Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene. 521(1):69-77
- De Wit, M., Keil, D., van der Ven, K., Vandamme, S., Witters, E., and De Coen, W. (2010) An integrated transcriptomic and proteomic approach characterising estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). General and comparative endocrinology. 167(2):190-201
- Hsu, R.J., Yang, H.J., and Tsai, H.J. (2009) Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs. Nucleic acids research. 37(10):e77
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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