Gene
suclg1
- ID
- ZDB-GENE-040912-101
- Name
- succinate-CoA ligase GDP/ADP-forming subunit alph
- Symbol
- suclg1 Nomenclature History
- Previous Names
-
- SUCLGa (1)
- zgc:103729
- zgc:92738
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have nucleoside diphosphate kinase activity and succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in nucleoside phosphate metabolic process; succinate metabolic process; and tricarboxylic acid cycle. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and solid lens vesicle. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908198 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 9 | Alliance | Mitochondrial DNA depletion syndrome 9 (encephalomyopathic type with methylmalonic aciduria) | 245400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR017440 | ATP-citrate lyase/succinyl-CoA ligase, active site |
| Conserved_site | IPR033847 | ATP-citrate lyase/succinyl-CoA ligase, conserved site |
| Domain | IPR003781 | CoA-binding |
| Domain | IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain |
| Family | IPR005810 | Succinyl-CoA ligase, alpha subunit |
| Homologous_superfamily | IPR016102 | Succinyl-CoA synthetase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ATP-citrate lyase/succinyl-CoA ligase, active site | ATP-citrate lyase/succinyl-CoA ligase, conserved site | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | CoA-binding | NAD(P)-binding domain superfamily | Succinyl-CoA ligase, alpha subunit | Succinyl-CoA synthetase-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I58
|
324 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
suclg1-201
(1)
|
Ensembl | 1,378 nt | ||
| ncRNA |
suclg1-002
(1)
|
Ensembl | 803 nt |
Interactions and Pathways
No data available
Plasmids
No data available