Gene
suclg1
- ID
- ZDB-GENE-040912-101
- Name
- succinate-CoA ligase GDP/ADP-forming subunit alph
- Symbol
- suclg1 Nomenclature History
- Previous Names
-
- SUCLGa (1)
- zgc:103729
- zgc:92738
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to localize to mitochondrion and succinate-CoA ligase complex (ADP-forming). Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908198 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 9 | Alliance | Mitochondrial DNA depletion syndrome 9 (encephalomyopathic type with methylmalonic aciduria) | 245400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR017440 | ATP-citrate lyase/succinyl-CoA ligase, active site |
| Conserved_site | IPR033847 | ATP-citrate lyase/succinyl-CoA ligase, conserved site |
| Domain | IPR003781 | CoA-binding |
| Domain | IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain |
| Family | IPR005810 | Succinyl-CoA ligase, alpha subunit |
| Homologous_superfamily | IPR016102 | Succinyl-CoA synthetase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ATP-citrate lyase/succinyl-CoA ligase, active site | ATP-citrate lyase/succinyl-CoA ligase, conserved site | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | CoA-binding | NAD(P)-binding domain superfamily | Succinyl-CoA ligase, alpha subunit | Succinyl-CoA synthetase-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I58
|
324 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
suclg1-201
(1)
|
Ensembl | 1,378 nt | ||
| ncRNA |
suclg1-002
(1)
|
Ensembl | 803 nt |
Interactions and Pathways
No data available
Plasmids
No data available