Gene
sf3a3
- ID
- ZDB-GENE-040908-1
- Name
- splicing factor 3a, subunit 3
- Symbol
- sf3a3 Nomenclature History
- Previous Names
-
- wu:fi15a06
- wu:fj94f01
- zgc:110227
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human SF3A3 (splicing factor 3a subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139354 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct83aGt | Transgenic insertion | Unknown | Unknown | DNA | |
| hi1950Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa12602 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18610 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39239 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43249 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Matrin/U1-C, C2H2-type zinc finger | RNA Processing and DNA Damage Response Regulator | SDE2/SF3A3, SAP domain | SF3A3 domain | Splicing factor SF3a60 binding domain | Splicing factor SF3a60 /Prp9 subunit, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DRK2 | InterPro | 501 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-30B16 | ZFIN Curated Data | |
| Encodes | EST | fi15a06 | ZFIN Curated Data | |
| Encodes | EST | fj94f01 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7139354 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:109878 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110227 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192710 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004289 (1) | 2216 nt | ||
| Genomic | GenBank:CR925717 (1) | 103832 nt | ||
| Polypeptide | UniProtKB:Q6DRK2 (1) | 501 aa |
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Trinh, A., Hochgreb, T., Graham, M., Wu, D., Ruf-Zamojski, F., Jayasena, C.S., Saxena, A., Hawk, R., Gonzalez-Serricchio, A., Dixson, A., Chow, E., Gonzales, C., Leung, H.Y., Solomon, I., Bronner-Fraser, M., Megason, S.G., and Fraser, S.E. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes & Development. 25(21):2306-20
- Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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