Gene
furinb
- ID
- ZDB-GENE-040901-2
- Name
- furin (paired basic amino acid cleaving enzyme) b
- Symbol
- furinb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within cartilage development and intrahepatic bile duct development. Predicted to be located in endomembrane system and membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; integument; liver; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023827 | Peptidase S8, subtilisin, Asp-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR002884 | P domain |
| Domain | IPR032815 | Peptidase S8, pro-domain |
| Domain | IPR034182 | Kexin/furin catalytic domain |
| Family | IPR015500 | Peptidase S8, subtilisin-related |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036852 | Peptidase S8/S53 domain superfamily |
| Homologous_superfamily | IPR038466 | Peptidase S8, pro-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Furin-like repeat | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Kexin/furin catalytic domain | P domain | Peptidase S8, pro-domain | Peptidase S8, pro-domain superfamily | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, Asp-active site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QKU2 | InterPro | 823 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
furinb-201
(1)
|
Ensembl | 3,427 nt | ||
| mRNA |
furinb-202
(1)
|
Ensembl | 897 nt |
Interactions and Pathways
No data available
Plasmids
No data available