Gene

ect2

ID

ZDB-GENE-040831-2

Name

epithelial cell transforming 2

Symbol

ect2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within cytokinetic process. Predicted to be located in cytoplasm. Predicted to be active in cell cortex and nucleus. Is expressed in midbrain. Orthologous to human ECT2 (epithelial cell transforming 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ect2 Human Ortholog

No data available

Associated With ect2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001357	BRCT domain
Domain	IPR049395	ECT2, PH domain
Domain	IPR049396	ECT2, BRCT0 domain
Family	IPR026817	Guanine nucleotide exchange factor Ect2
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036420	BRCT domain superfamily

Domain Details Per Protein

Protein	Length	BRCT domain	BRCT domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	ECT2, BRCT0 domain	ECT2, PH domain	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Guanine nucleotide exchange factor Ect2	PH-like domain superfamily
UniProtKB:A0A8M2B1T9 InterPro	946
UniProtKB:Q6DRB9 InterPro	878
UniProtKB:F1QVS6 InterPro	976
UniProtKB:A0A2R8Q1Z1 InterPro	980
UniProtKB:A0A8M2B2N3 InterPro	1012

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ect2-201 (1) Ensembl	Ensembl	3,054 nt	Select Tool ZFIN BLAST
mRNA	ect2-202 (1) Ensembl	Ensembl	4,186 nt	Select Tool ZFIN BLAST
mRNA	ect2-203 (1) Ensembl	Ensembl	4,793 nt	Select Tool ZFIN BLAST
mRNA	ect2-204 (1) Ensembl	Ensembl	8,427 nt	Select Tool ZFIN BLAST
mRNA	ect2-205 (1) Ensembl	Ensembl	8,263 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations