Gene
sars1
- ID
- ZDB-GENE-040831-1
- Name
- seryl-tRNA synthetase 1
- Symbol
- sars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Exhibits serine-tRNA ligase activity. Involved in several processes, including negative regulation of vascular endothelial growth factor production; seryl-tRNA aminoacylation; and vasculature development. Localizes to nucleus. Used to study arteriovenous malformations of the brain. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908380 (8 images)
- IMAGE:7155143 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly, ataxia, and seizures | 617709 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| arteriovenous malformations of the brain | pku6Tg + MO1-sars1 | standard conditions | Wang et al., 2018 |
| arteriovenous malformations of the brain | pku6Tg + MO4-sars1 | standard conditions | Wang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR015866 | Serine-tRNA synthetase, type1, N-terminal |
| Domain | IPR033729 | Serine-tRNA ligase catalytic core domain |
| Family | IPR002317 | Serine-tRNA ligase, type1 |
| Homologous_superfamily | IPR010978 | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm |
| Homologous_superfamily | IPR042103 | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Serine-tRNA ligase catalytic core domain | Serine-tRNA ligase, type1 | Serine-tRNA synthetase, type1, N-terminal | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRC0
|
515 |
Interactions and Pathways
No data available
Plasmids
No data available