Gene
polb
- ID
- ZDB-GENE-040830-1
- Name
- polymerase (DNA directed), beta
- Symbol
- polb Nomenclature History
- Previous Names
-
- DNA polymerase beta (1)
- wu:fa97a05
- zgc:109924
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables DNA-directed DNA polymerase activity. Predicted to be involved in base-excision repair and double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within DNA biosynthetic process; DNA repair; and DNA replication. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898371 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019843 | DNA polymerase family X, binding site |
| Domain | IPR002054 | DNA-directed DNA polymerase X |
| Domain | IPR003583 | Helix-hairpin-helix DNA-binding motif, class 1 |
| Domain | IPR010996 | DNA polymerase beta-like, N-terminal domain |
| Domain | IPR018944 | DNA polymerase lambda, fingers domain |
| Domain | IPR028207 | DNA polymerase beta, palm domain |
| Domain | IPR029398 | DNA polymerase beta, thumb domain |
| Family | IPR002008 | DNA polymerase family X, beta-like |
| Family | IPR022312 | DNA polymerase family X |
| Homologous_superfamily | IPR027421 | DNA polymerase lambda lyase domain superfamily |
| Homologous_superfamily | IPR037160 | DNA polymerase, thumb domain superfamily |
| Homologous_superfamily | IPR043519 | Nucleotidyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | DNA-directed DNA polymerase X | DNA polymerase beta-like, N-terminal domain | DNA polymerase beta, palm domain | DNA polymerase beta, thumb domain | DNA polymerase family X | DNA polymerase family X, beta-like | DNA polymerase family X, binding site | DNA polymerase lambda, fingers domain | DNA polymerase lambda lyase domain superfamily | DNA polymerase, thumb domain superfamily | Helix-hairpin-helix DNA-binding motif, class 1 | Nucleotidyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRD3
|
336 | ||||||||||||
|
UniProtKB:B0R194
|
339 |
Interactions and Pathways
No data available
Plasmids
No data available