Gene
polb
- ID
- ZDB-GENE-040830-1
- Name
- polymerase (DNA directed), beta
- Symbol
- polb Nomenclature History
- Previous Names
-
- DNA polymerase beta (1)
- wu:fa97a05
- zgc:109924
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Exhibits DNA-directed DNA polymerase activity. Predicted to be involved in base-excision repair and double-strand break repair via nonhomologous end joining. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898371 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019843 | DNA polymerase family X, binding site |
| Domain | IPR002054 | DNA-directed DNA polymerase X |
| Domain | IPR003583 | Helix-hairpin-helix DNA-binding motif, class 1 |
| Domain | IPR010996 | DNA polymerase beta-like, N-terminal domain |
| Domain | IPR018944 | DNA polymerase lambda, fingers domain |
| Domain | IPR028207 | DNA polymerase beta, palm domain |
| Domain | IPR029398 | DNA polymerase beta, thumb domain |
| Family | IPR002008 | DNA polymerase family X, beta-like |
| Family | IPR022312 | DNA polymerase family X |
| Homologous_superfamily | IPR027421 | DNA polymerase lambda lyase domain superfamily |
| Homologous_superfamily | IPR037160 | DNA polymerase, thumb domain superfamily |
| Homologous_superfamily | IPR043519 | Nucleotidyltransferase superfamily |
Domain Details Per Protein
| Protein | Length | DNA-directed DNA polymerase X | DNA polymerase beta-like, N-terminal domain | DNA polymerase beta, palm domain | DNA polymerase beta, thumb domain | DNA polymerase family X | DNA polymerase family X, beta-like | DNA polymerase family X, binding site | DNA polymerase lambda, fingers domain | DNA polymerase lambda lyase domain superfamily | DNA polymerase, thumb domain superfamily | Helix-hairpin-helix DNA-binding motif, class 1 | Nucleotidyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRD3
|
336 | ||||||||||||
|
UniProtKB:B0R194
|
339 |
Interactions and Pathways
No data available
Plasmids
No data available