Gene

pkd2

ID
ZDB-GENE-040827-4
Name
polycystic kidney disease 2
Symbol
pkd2 Nomenclature History
Previous Names
  • cup (1)
  • curly up (1)
  • polycystin-2 (1)
  • TRPP2 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have several functions, including calcium ion binding activity; cation channel activity; and muscle alpha-actinin binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and regionalization. Localizes to basolateral plasma membrane; cilium; and endoplasmic reticulum. Is expressed in several structures, including germ ring; heart; nervous system; pleuroperitoneal region; and tail bud. Used to study autosomal dominant polycystic kidney disease and polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel).
Genome Resources
Note
None
Expression
All Expression Data
25 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
92 figures from 42 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pkd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
polycystic kidney disease 2 Alliance Polycystic kidney disease 2 613095
Associated With pkd2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002048 EF-hand domain
Domain IPR013122 Polycystin cation channel, PKD1/PKD2
Family IPR003915 Polycystic kidney disease type 2 protein
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length EF-hand domain EF-hand domain pair Polycystic kidney disease type 2 protein Polycystin cation channel, PKD1/PKD2 Voltage-dependent channel domain superfamily
UniProtKB:Q6IVV8 904
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-pkd2 monoclonal IgG2b , k Mouse
  • WB
2
Ab2-pkd2 polyclonal IgG Rabbit
  • IHC
GeneTex
2
Ab1-pkd2 polyclonal Rabbit
  • IHC
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations