Gene
dstyk
- ID
- ZDB-GENE-040826-2
- Name
- dual serine/threonine and tyrosine protein kinase
- Symbol
- dstyk Nomenclature History
- Previous Names
-
- ripk5
- zgc:136421
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein kinase activity. Involved in embryonic organ development. Acts upstream of or within notochord cell vacuolation and notochord morphogenesis. Predicted to be located in anchoring junction; apical plasma membrane; and basolateral plasma membrane. Predicted to be active in cytoplasm. Is expressed in head and notochord. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR051302 | Dual Ser/Thr and Tyr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dual Ser/Thr and Tyr Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4VSN1 | InterPro | 885 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available