Gene

dstyk

ID

ZDB-GENE-040826-2

Name

dual serine/threonine and tyrosine protein kinase

Symbol

dstyk Nomenclature History

Previous Names

ripk5
zgc:136421

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and protein kinase activity. Involved in embryonic organ development. Acts upstream of or within notochord cell vacuolation and notochord morphogenesis. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and cell junction. Predicted to be active in cytoplasm. Is expressed in head and notochord. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dstyk Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
CAKUT1	Alliance	Congenital anomalies of kidney and urinary tract 1	610805
hereditary spastic paraplegia 23	Alliance	Spastic paraplegia 23, autosomal recessive	270750

Associated With dstyk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR051302	Dual Ser/Thr and Tyr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily