Gene

rela

ID
ZDB-GENE-040825-4
Name
v-rel avian reticuloendotheliosis viral oncogene homolog A
Symbol
rela Nomenclature History
Previous Names
  • nfkb3
  • p65 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within anterior/posterior axis specification; mesoderm development; and regulation of apoptotic process. Located in nucleus. Is expressed in intestine and male organism. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rela Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Mucocutaneous ulceration, chronic 618287
Associated With rela Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030492 Rel homology domain, conserved site
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain (RHD), DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Domain IPR033926 NFkappaB IPT domain
Family IPR000451 NF-kappa-B/Dorsal
Family IPR030495 Transcription factor RelA (p65)
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain NF-kappa-B/Dorsal NFkappaB IPT domain p53-like transcription factor, DNA-binding Rel homology dimerisation domain Rel homology domain, conserved site Rel homology domain (RHD), DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily Transcription factor RelA (p65)
UniProtKB:Q6K197 455
UniProtKB:B3DHW2 455
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-rela polyclonal IgG Rabbit
  • IHC
Thermo Fisher Scientific (Lab Vision)
3
Ab1-rela polyclonal IgG Rabbit
  • IHC
Abcam plc
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations