Gene
snrnp70
- ID
- ZDB-GENE-040825-2
- Name
- small nuclear ribonucleoprotein 70 (U1)
- Symbol
- snrnp70 Nomenclature History
- Previous Names
-
- snrp70
- U1 small ribonucleoprotein 70kd (1)
- wu:fc20b04
- zgc:136450
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable U1 snRNA binding activity and mRNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in central nervous system; hematopoietic stem cell; and motor neurons. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147833 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3018aTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| kg163 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| la015168Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa976 | Allele with one point mutation | Unknown | Missense, Premature Stop | ENU | |
| sa8712 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-snrnp70 | Nikolaou et al., 2022 | |
| MO1-snrnp70 | N/A | Yu et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR022023 | U1 small nuclear ribonucleoprotein of 70kDa N-terminal |
| Domain | IPR034143 | snRNP70, RNA recognition motif |
| Family | IPR051183 | U1 snRNP 70 kDa and U11/U12 snRNP 35 kDa |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | snRNP70, RNA recognition motif | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | U1 snRNP 70 kDa and U11/U12 snRNP 35 kDa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DRE8 | InterPro | 495 | ||||||
| UniProtKB:E7EY23 | InterPro | 162 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
snrnp70-201
(1)
|
Ensembl | 2,488 nt | ||
| mRNA |
snrnp70-202
(1)
|
Ensembl | 885 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-15N1 | ZFIN Curated Data | |
| Encodes | EST | fc20b04 | ||
| Encodes | EST | IMAGE:7147833 | Thisse et al., 2004 | |
| Encodes | EST | tdsubc_1d10 | ||
| Encodes | cDNA | MGC:136450 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003875 (1) | 2501 nt | ||
| Genomic | GenBank:BX324157 (1) | 272769 nt | ||
| Polypeptide | UniProtKB:Q6DRE8 (1) | 495 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SNRNP70 | 19 | Amino acid sequence comparison (1) |
- Nikolaou, N., Gordon, P.M., Hamid, F., Taylor, R., Lloyd-Jones, J., Makeyev, E.V., Houart, C. (2022) Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity. Current biology : CB. 32(23):5099-5115.e8
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yu, Y., Chi, B., Xia, W., Gangopadhyay, J., Yamazaki, T., Winkelbauer-Hurt, M.E., Yin, S., Eliasse, Y., Adams, E., Shaw, C.E., Reed, R. (2015) U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish. Nucleic acids research. 43(6):3208-18
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Bolli, N., Payne, E.M., Rhodes, J., Gjini, E., Johnston, A.B., Guo, F., Lee, J.S., Stewart, R.A., Kanki, J.P., Chen, A.T., Zhou, Y., Zon, L.I., and Look, A.T. (2011) cpsf1 is required for definitive HSC survival in zebrafish. Blood. 117(15):3996-4007
- Burns, C.E., Galloway, J.L., Smith, A.C., Keefe, M.D., Cashman, T.J., Paik, E.J., Mayhall, E.A., Amsterdam, A.H., and Zon, L.I. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 113(23):5776-5782
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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