Gene

her12

ID
ZDB-GENE-040824-5
Name
hairy-related 12
Symbol
her12 Nomenclature History
Previous Names
  • Hes5c (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within Notch signaling pathway; brain development; and somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; nervous system; neural plate; tail bud; and trunk vasculature. Orthologous to human HES5 (hes family bHLH transcription factor 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la014348TgTransgenic insertionUnknownUnknownDNA
la028498TgTransgenic insertionUnknownUnknownDNA
sa24312Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-her12N/AShankaran et al., 2007
MO2-her12N/ASchwendinger-Schreck et al., 2014
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Human Disease
Associated With her12 Human Ortholog
No data available
Associated With her12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR050370 Hairy and Enhancer of Split/HEY-related
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Hairy and Enhancer of Split/HEY-related Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain
UniProtKB:Q6TA36 InterPro 155
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 23
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA her12-201 (1) Ensembl 1,050 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(her12:Kaede)
  • her12
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-21G5ZFIN Curated Data
EncodesESTIMAGE:6904047Thisse et al., 2004
EncodescDNAMGC:86804ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
1 - 10 of 43
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