Gene

crbn

ID
ZDB-GENE-040822-43
Name
cereblon
Symbol
crbn Nomenclature History
Previous Names
  • zgc:92404 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity. Involved in cell population proliferation; embryonic pectoral fin morphogenesis; and otic vesicle morphogenesis. Localizes to ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crbn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 2 607417
Associated With crbn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003111 Lon, substrate-binding domain
Domain IPR004910 Yippee/Mis18/Cereblon
Domain IPR034750 CULT domain
Homologous_superfamily IPR015947 PUA-like superfamily
Domain Details Per Protein
Protein Length CULT domain Lon, substrate-binding domain PUA-like superfamily Yippee/Mis18/Cereblon
UniProtKB:B2GQH0 431
UniProtKB:F1QCS1 446
UniProtKB:Q68EH9 431
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-crbn Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations