Gene

ak1

ID

ZDB-GENE-040822-37

Name

adenylate kinase 1

Symbol

ak1 Nomenclature History

Previous Names

zgc:91930 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in ATP metabolic process; nucleoside phosphate metabolic process; and phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Is expressed in cephalic musculature; hypaxial myotome region; myotome; pectoral fin musculature; and somite. Orthologous to human AK1 (adenylate kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6899635 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ak1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 3	Alliance	Anemia, congenital, nonspherocytic hemolytic, 3, adenylate kinase deficient	612631

Associated With ak1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR033690	Adenylate kinase, conserved site
Family	IPR000850	Adenylate kinase/UMP-CMP kinase
Family	IPR006267	Adenylate kinase, isozyme 1/5
Family	IPR028582	Adenylate kinase isoenzyme 1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Adenylate kinase, conserved site	Adenylate kinase isoenzyme 1	Adenylate kinase, isozyme 1/5	Adenylate kinase/UMP-CMP kinase	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2BGJ7 InterPro	209
UniProtKB:Q68EH2 InterPro PDB	194

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ak1-201 (1) Ensembl	Ensembl		897 nt	Select Tool ZFIN BLAST
mRNA	ak1-202 (1) Ensembl	Ensembl		585 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations