Gene

grb10a

ID

ZDB-GENE-040822-32

Name

growth factor receptor-bound protein 10a

Symbol

grb10a Nomenclature History

Previous Names

grb10
zgc:91987

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have SH3/SH2 adaptor activity and insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Orthologous to human GRB10 (growth factor receptor bound protein 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7142951 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grb10a Human Ortholog

No data available

Associated With grb10a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR000980	SH2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015042	BPS (Between PH and SH2) domain
Domain	IPR035037	Grb10, SH2
Domain	IPR039665	APBB1IP, PH domain
Family	IPR039664	GRB/APBB1IP
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily