Gene
caprin2
- ID
- ZDB-GENE-040812-2
- Name
- caprin family member 2
- Symbol
- caprin2 Nomenclature History
- Previous Names
-
- c1qdc1 (1)
- wu:fj80b02
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Involved in dorsal/ventral axis specification and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within dorsal/ventral pattern formation and positive regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human CAPRIN2 (caprin family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ding et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ding et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6049 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12256 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12716 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14869 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-caprin2 | N/A | Ding et al., 2008 |
| MO2-caprin2 | N/A | Ding et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Caprin | Caprin-1 dimerization domain | Cytoplasmic activation/proliferation-associated protein-1 C term | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RJ80 | InterPro PDB | 914 | |||||
| UniProtKB:B7ZVU9 | InterPro | 914 | |||||
| UniProtKB:A0AB32TJV9 | InterPro | 934 | |||||
| UniProtKB:A0AB32TL87 | InterPro | 908 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
caprin2-201
(1)
|
Ensembl | 3,625 nt | ||
| mRNA |
caprin2-202
(1)
|
Ensembl | 1,870 nt |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-11C20 | ZFIN Curated Data | |
| Encodes | EST | fj80b02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171363 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198441 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013273 (1) | 3625 nt | ||
| Genomic | GenBank:BX001012 (1) | 158481 nt | ||
| Polypeptide | UniProtKB:A0AB32TJV9 (1) | 934 aa |
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Boke, E., Ruer, M., Wühr, M., Coughlin, M., Lemaitre, R., Gygi, S.P., Alberti, S., Drechsel, D., Hyman, A.A., Mitchison, T.J. (2016) Amyloid-like Self-Assembly of a Cellular Compartment. Cell. 166:637-50
- Li, I.C., Chan, C.T., Lu, Y.F., Wu, Y.T., Chen, Y.C., Li, G.B., Lin, C.Y., and Hwang, S.P. (2011) Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. PLoS One. 6(6):e20974
- Hu, Y.L., Pan, X.M., Xiang, L.X., and Shao, J.Z. (2010) Characterization of C1Q in teleosts: insight into the molecular and functional evolution of C1Q family and classical pathway. The Journal of biological chemistry. 285(37):28777-28786
- Ding, Y., Xi, Y., Chen, T., Wang, J.Y., Tao, D.L., Wu, Z.L., Li, Y.P., Li, C., Zeng, R., and Li, L. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. The Journal of cell biology. 182(5):865-872
- Mei, J., and Gui, J. (2008) Bioinformatic identification of genes encoding C1q-domain-containing proteins in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 35(1):17-24
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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