Gene

kras

ID
ZDB-GENE-040808-67
Name
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Symbol
kras Nomenclature History
Previous Names
  • fa04e08
  • fc14b12
  • fc23g10
  • fj89d12
  • wu:fa04e08
  • wu:fc14b12
  • wu:fc23g10
  • wu:fj89d12
  • xRAS2 (1)
  • zgc:85725
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Involved in embryonic cranial skeleton morphogenesis; heart development; and hemopoiesis. Predicted to localize to plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from Liu et al., 2008
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kras Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
arteriovenous malformations of the brain Alliance Arteriovenous malformation of the brain, somatic 108010
autoimmune lymphoproliferative syndrome type 4 Alliance RAS-associated autoimmune leukoproliferative disorder 614470
breast cancer Alliance Breast cancer, somatic 114480
cardiofaciocutaneous syndrome 2 Alliance Cardiofaciocutaneous syndrome 2 615278
hereditary diffuse gastric cancer Alliance Gastric cancer, somatic 137215
linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
lung cancer Alliance Lung cancer, somatic 211980
Noonan syndrome 3 Alliance Noonan syndrome 3 609942
oculoectodermal syndrome Alliance Oculoectodermal syndrome, somatic 600268
pancreatic carcinoma Alliance Pancreatic carcinoma, somatic 260350
urinary bladder cancer Alliance Bladder cancer, somatic 109800
Associated With kras Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR020849 Small GTPase superfamily, Ras-type
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase superfamily, Ras-type Small GTP-binding protein domain
UniProtKB:A0A2R8Q8S1 189
UniProtKB:Q6AZA4 188
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations