Gene
akr1a1a
- ID
- ZDB-GENE-040808-44
- Name
- aldo-keto reductase family 1, member A1a (aldehyde reductase)
- Symbol
- akr1a1a Nomenclature History
- Previous Names
-
- akr1a1
- zgc:100940
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable aldose reductase (NADPH) activity and all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within glucose homeostasis and sprouting angiogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146346 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Qi et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3750 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018170 | Aldo/keto reductase, conserved site |
| Domain | IPR023210 | NADP-dependent oxidoreductase domain |
| Family | IPR020471 | Aldo-keto reductase |
| Family | IPR044481 | Aldo-keto reductase family 1 member A1 |
| Homologous_superfamily | IPR036812 | NADP-dependent oxidoreductase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldo-keto reductase | Aldo/keto reductase, conserved site | Aldo-keto reductase family 1 member A1 | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AZW2 | InterPro | 324 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
akr1a1a-201
(1)
|
Ensembl | 1,098 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-akr1a1a | polyclonal | Guinea pig |
|
2 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113N10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-165I4 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7146346 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100940 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003783 (1) | 1116 nt | ||
| Genomic | GenBank:CR735112 (1) | 156543 nt | ||
| Polypeptide | UniProtKB:Q6AZW2 (1) | 324 aa |
- Qi, H., Schmöhl, F., Li, X., Qian, X., Tabler, C.T., Bennewitz, K., Sticht, C., Morgenstern, J., Fleming, T., Volk, N., Hausser, I., Heidenreich, E., Hell, R., Nawroth, P.P., Kroll, J. (2021) Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 8(18):e2101281
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Warner, C.M., Gust, K.A., Stanley, J.K., Habib, T., Wilbanks, M.S., Garcia-Reyero, N., and Perkins, E.J. (2012) A Systems Toxicology Approach to Elucidate the Mechanisms Involved in RDX Species-Specific Sensitivity. Environmental science & technology. 46(14):7790-7798
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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