akr1a1a

ID

ZDB-GENE-040808-44

Name

aldo-keto reductase family 1, member A1a (aldehyde reductase)

Symbol

akr1a1a Nomenclature History

Previous Names

akr1a1
zgc:100940

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable aldose reductase (NADPH) activity and all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within glucose homeostasis and sprouting angiogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146346 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Qi et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With akr1a1a Human Ortholog

No data available

Associated With akr1a1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018170	Aldo/keto reductase, conserved site
Domain	IPR023210	NADP-dependent oxidoreductase domain
Family	IPR020471	Aldo-keto reductase
Family	IPR044481	Aldo-keto reductase family 1 member A1
Homologous_superfamily	IPR036812	NADP-dependent oxidoreductase domain superfamily