Gene

nrros

ID
ZDB-GENE-040808-36
Name
negative regulator of reactive oxygen species
Symbol
nrros Nomenclature History
Previous Names
  • lrrc33
  • zgc:100989
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable growth factor binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nrros Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Seizures, early-onset, with neurodegeneration and brain calcification 618875
Associated With nrros Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype
UniProtKB:G1K2U4 685
UniProtKB:Q6AXL3 685
UniProtKB:A8BAZ0 640
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations