Gene
nrros
- ID
- ZDB-GENE-040808-36
- Name
- negative regulator of reactive oxygen species
- Symbol
- nrros Nomenclature History
- Previous Names
-
- lrrc33
- zgc:100989
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable receptor ligand inhibitor activity. Predicted to be involved in several processes, including inflammatory response; microglia development; and sequestering of TGFbeta in extracellular matrix. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148958 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Seizures, early-onset, with neurodegeneration and brain calcification | 618875 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BspA-type LRR region | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Multifunctional Developmental and Immune Receptor |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AXL3 | InterPro | 685 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available