Gene

nrros

ID
ZDB-GENE-040808-36
Name
negative regulator of reactive oxygen species
Symbol
nrros Nomenclature History
Previous Names
  • lrrc33
  • zgc:100989
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable receptor ligand inhibitor activity. Predicted to be involved in several processes, including inflammatory response; microglia development; and sequestering of TGFbeta in extracellular matrix. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa37914Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With nrros Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Seizures, early-onset, with neurodegeneration and brain calcification 618875
1 - 1 of 1
Associated With nrros Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR050328 Multifunctional Developmental and Immune Receptor
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR026906 BspA-type LRR region
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Domain Details Per Protein
Protein Additional Resources Length BspA-type LRR region Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Multifunctional Developmental and Immune Receptor
UniProtKB:Q6AXL3 InterPro 685
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 24
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nrros-201 (1) Ensembl 2,351 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-165P10ZFIN Curated Data
Contained inBACCH73-367C9ZFIN Curated Data
Contained inBACCH211-244M18
EncodesESTIMAGE:7148958Thisse et al., 2004
EncodescDNAMGC:100989ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanNRROS3
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseNrros16
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 6 of 6
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