Gene
nrros
- ID
- ZDB-GENE-040808-36
- Name
- negative regulator of reactive oxygen species
- Symbol
- nrros Nomenclature History
- Previous Names
-
- lrrc33
- zgc:100989
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable receptor ligand inhibitor activity. Predicted to be involved in several processes, including inflammatory response; microglia development; and sequestering of TGFbeta in extracellular matrix. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148958 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37914 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Seizures, early-onset, with neurodegeneration and brain calcification | 618875 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR050328 | Multifunctional Developmental and Immune Receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR026906 | BspA-type LRR region |
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Domain Details Per Protein
| Protein | Additional Resources | Length | BspA-type LRR region | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Multifunctional Developmental and Immune Receptor |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AXL3 | InterPro | 685 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-165P10 | ZFIN Curated Data | |
| Contained in | BAC | CH73-367C9 | ZFIN Curated Data | |
| Contained in | BAC | CH211-244M18 | ||
| Encodes | EST | IMAGE:7148958 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100989 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003775 (1) | 2381 nt | ||
| Genomic | GenBank:CR847905 (1) | 153307 nt | ||
| Polypeptide | UniProtKB:Q6AXL3 (1) | 685 aa |
- Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A.A., Mialhe, X., Gualda, E., Loza-Alvarez, P., Blanc-Potard, A., Lutfalla, G., Nguyen-Chi, M.E. (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. eLIFE. 13:
- Peterson, E.A., Sun, J., Chen, X., Wang, J. (2024) Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Developmental Biology. 508:93-106
- Heylen, L., Pham, D.H., De Meulemeester, A.S., Samarut, É., Skiba, A., Copmans, D., Kazwiny, Y., Vanden Berghe, P., de Witte, P.A.M., Siekierska, A. (2021) Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Frontiers in molecular neuroscience. 14:753936
- Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S., and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994
- Qian, F., Zhen, F., Ong, C., Jin, S.W., Meng Soo, H., Stainier, D.Y., Lin, S., Peng, J., and Wen, Z. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1163-1172
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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