Gene
sumo2b
- ID
- ZDB-GENE-040801-7
- Name
- small ubiquitin like modifier 2b
- Symbol
- sumo2b Nomenclature History
- Previous Names
-
- sumo2
- zgc:92241
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable protein tag activity and ubiquitin-like protein ligase binding activity. Acts upstream of or within chordate embryonic development and definitive hemopoiesis. Predicted to be active in nucleus. Is expressed in brain; cranial neural crest cell; digestive system; eye; and pectoral fin bud. Orthologous to human SUMO2 (small ubiquitin like modifier 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yuan et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024379Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa39984 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45129 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Rad60/SUMO-like domain | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6DHL4 | InterPro | 96 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sumo2b-201
(1)
|
Ensembl | 869 nt | ||
| mRNA |
sumo2b-202
(1)
|
Ensembl | 834 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-157I16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-239G19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92241 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003422 (1) | 940 nt | ||
| Genomic | GenBank:CU929417 (2) | 78125 nt | ||
| Polypeptide | UniProtKB:Q6DHL4 (1) | 96 aa |
- Nepal, C., Hadzhiev, Y., Balwierz, P., Tarifeño-Saldivia, E., Cardenas, R., Wragg, J.W., Suzuki, A.M., Carninci, P., Peers, B., Lenhard, B., Andersen, J.B., Müller, F. (2020) Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing. Nature communications. 11:168
- Wang, L., Liu, X., Wang, H., Yuan, H., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2018) RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPα axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9):4930-4940
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wen, B., Yuan, H., Liu, X., Wang, H., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2017) GATA5 SUMOylation is indispensable for zebrafish cardiac development. Biochimica et biophysica acta. 1861(7):1691-1701
- Xu, M., Wei, J., Chen, X., Gao, P., Zhou, Y., Qin, Q. (2016) Molecular cloning and expression analysis of small ubiquitin-like modifier (SUMO) genes from grouper (Epinephelus coioides). Fish & shellfish immunology. 48:119-27
- Liu, X., Jia, X., Yuan, H., Ma, K., Chen, Y., Jin, Y., Deng, M., Pan, W., Chen, S., Chen, Z., de The, H., Zon, L.I., Zhou, Y., Zhou, J., Zhu, J. (2015) DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Journal of Hematology & Oncology. 8:15
- Yuan, H., Zhang, T., Liu, X., Deng, M., Zhang, W., Wen, Z., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports. 5:9011
- Jing, C.B., Chen, Y., Dong, M., Peng, X.L., Jia, X.E., Gao, L., Ma, K., Deng, M., Liu, T.X., Zon, L.I., Zhu, J., Zhou, Y., and Zhou, Y. (2013) Phospholipase c gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology. 374(1):24-31
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Yuan, H., Zhou, J., Deng, M., Zhang, Y., Chen, Y., Jin, Y., Zhu, J., Chen, S.J., The, H.D., Chen, Z., Liu, T.X., and Zhu, J. (2011) Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish. Blood. 117(26):7014-7020
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