Gene

mipa

ID
ZDB-GENE-040801-41
Name
major intrinsic protein of lens fiber a
Symbol
mipa Nomenclature History
Previous Names
  • mip1
  • aqp0a (1)
  • zgc:100858
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits water channel activity. Involved in lens fiber cell morphogenesis and water transport. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in eye; lens; lens fiber cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mipa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 15 multiple types Alliance Cataract 15, multiple types 615274
Associated With mipa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022357 Major intrinsic protein, conserved site
Family IPR000425 Major intrinsic protein
Family IPR034294 Aquaporin transporter
Homologous_superfamily IPR023271 Aquaporin-like
Domain Details Per Protein
Protein Length Aquaporin-like Aquaporin transporter Major intrinsic protein Major intrinsic protein, conserved site
UniProtKB:Q6DEI6 263
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mipa polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations