Gene
mipa
- ID
- ZDB-GENE-040801-41
- Name
- major intrinsic protein of lens fiber a
- Symbol
- mipa Nomenclature History
- Previous Names
-
- mip1
- aqp0a (1)
- zgc:100858
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables water channel activity. Acts upstream of or within lens fiber cell morphogenesis; maintenance of lens transparency; and water transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in eye; lens; lens fiber cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mipa | (4) | |
| CRISPR2-mipa | (2) | |
| MO1-mipa | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 15 multiple types | Alliance | Cataract 15, multiple types | 615274 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aquaporin-like | Aquaporin transporter | Major intrinsic protein | Major intrinsic protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:Q6DEI6
|
263 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-157G16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:100858 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003534 (1) | 2905 nt | ||
| Genomic | GenBank:CR361559 (1) | 246041 nt | ||
| Polypeptide | UniProtKB:Q6DEI6 (1) | 263 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Safrina, O., Vorontsova, I., Donaldson, P.J., Schilling, T.F. (2024) Zebrafish Optical Development Requires Regulated Water Permeability by Aquaporin 0. Investigative ophthalmology & visual science. 65:4242
- Jarayseh, T., Guillemyn, B., De Saffel, H., Bek, J.W., Syx, D., Symoens, S., Gansemans, Y., Van Nieuwerburgh, F., Jagadeesh, S., Raja, J., Malfait, F., Coucke, P.J., De Clercq, A., Willaert, A. (2023) A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract. Human genetics. 142(3):457-476
- Vorontsova, I., Vallmitjana, A., Torrado, B., Schilling, T.F., Hall, J.E., Gratton, E., Malacrida, L. (2022) In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging. Science advances. 8:eabj4833
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Jones, J.L., Corbett, M.A., Yeaman, E., Zhao, D., Gecz, J., Gasperini, R.J., Charlesworth, J.C., Mackey, D.A., Elder, J.E., Craig, J.E., Burdon, K.P. (2021) A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract. European journal of human genetics : EJHG. 29(8):1206-1215
- Vorontsova, I., Hall, J.E., Schilling, T.F., Nagai, N., Nakazawa, Y. (2021) Differences in a Single Extracellular Residue Underlie Adhesive Functions of Two Zebrafish Aqp0s. Cells. 10(8):
- Wang, K., Vorontsova, I., Hoshino, M., Uesugi, K., Yagi, N., Hall, J.E., Schilling, T.F., Pierscionek, B.K. (2021) Aquaporins Have Regional Functions in Development of Refractive Index in the Zebrafish Eye Lens. Investigative ophthalmology & visual science. 62:23
- Dong, Z., Li, Y., Chen, X., Lai, X., Liu, M. (2020) A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 251:110522
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
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