Gene
suz12a
- ID
- ZDB-GENE-040801-36
- Name
- SUZ12 polycomb repressive complex 2 subunit a
- Symbol
- suz12a Nomenclature History
- Previous Names
-
- suz12
- suz12l (1)
- zgc:100863
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable chromatin DNA binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be part of ESC/E(Z) complex and RSC-type complex. Predicted to be active in nucleus. Is expressed in gonad; midbrain hindbrain boundary; pharyngeal arch; and visual system. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156370 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Eckfeldt et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024161Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024163Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028913Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1522 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20077 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3456 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf3458 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf3460 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| zf3462 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-suz12a | (3) | |
| CRISPR2-suz12a | Gagnon et al., 2014 | |
| CRISPR3-suz12a | Oppel et al., 2020 | |
| CRISPR4-suz12a | Oppel et al., 2020 | |
| MO1-suz12a | N/A | (4) |
| MO2-suz12a | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Imagawa-Matsumoto syndrome | 618786 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019135 | Polycomb protein, VEFS-Box |
Domain Details Per Protein
| Protein | Additional Resources | Length | Polycomb protein, VEFS-Box |
|---|---|---|---|
| UniProtKB:Q6DC03 | InterPro | 657 | |
| UniProtKB:A0A8M9PR46 | InterPro | 656 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
suz12a-201
(1)
|
Ensembl | 4,263 nt | ||
| ncRNA |
suz12a-002
(1)
|
Ensembl | 703 nt | ||
| ncRNA |
suz12a-003
(1)
|
Ensembl | 805 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-168A10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7156370 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100863 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173817 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003529 (1) | 2612 nt | ||
| Genomic | GenBank:CR926458 (1) | 261898 nt | ||
| Polypeptide | UniProtKB:Q6DC03 (1) | 657 aa |
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Oppel, F., Ki, D.H., Zimmermann, M.W., Ross, K.N., Tao, T., Shi, H., He, S., Aster, J.C., Look, A.T. (2020) suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma. Disease models & mechanisms. 13(8):
- Chrispijn, N.D., Andralojc, K.M., Castenmiller, C., Kamminga, L.M. (2018) Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. PLoS One. 13:e0200316
- Wu, X., Shen, W., Zhang, B., Meng, A. (2018) The genetic program of oocytes can be modified in vivo in the zebrafish ovary. Journal of molecular cell biology. 10(6):479-493
- Louie, K.W., Saera-Vila, A., Kish, P.E., Colacino, J.A., Kahana, A. (2017) Temporally distinct transcriptional regulation of myocyte dedifferentiation and Myofiber growth during muscle regeneration. BMC Genomics. 18:854
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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