Gene
sdhc
- ID
- ZDB-GENE-040801-26
- Name
- succinate dehydrogenase complex, subunit C, integral membrane protein
- Symbol
- sdhc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have electron transfer activity; metal ion binding activity; and succinate dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7143291 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carney-Stratakis syndrome | Alliance | Paraganglioma and gastric stromal sarcoma | 606864 |
| gastrointestinal stromal tumor | Alliance | Gastrointestinal stromal tumor | 606764 |
| paraganglioma | Alliance | Pheochromocytoma/paraganglioma syndrome 3 | 605373 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018495 | Succinate dehydrogenase, cytochrome b subunit, conserved site |
| Family | IPR000701 | Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit |
| Family | IPR014314 | Succinate dehydrogenase, cytochrome b556 subunit |
| Homologous_superfamily | IPR034804 | Fumarate reductase/succinate dehydrogenase, transmembrane subunit |
Domain Details Per Protein
| Protein | Length | Fumarate reductase/succinate dehydrogenase, transmembrane subunit | Succinate dehydrogenase, cytochrome b556 subunit | Succinate dehydrogenase, cytochrome b subunit, conserved site | Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit |
|---|---|---|---|---|---|
|
UniProtKB:B0S5Q2
|
169 |
Interactions and Pathways
No data available
Plasmids
No data available