Gene

alkbh3

ID

ZDB-GENE-040801-254

Name

alkB homolog 3, alpha-ketoglutarate dependent dioxygenase

Symbol

alkbh3 Nomenclature History

Previous Names

im:6900103
zgc:91935 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable broad specificity oxidative DNA demethylase activity and mRNA N1-methyladenosine dioxygenase activity. Acts upstream of or within cilium assembly. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion and nucleoplasm. Is expressed in brain. Orthologous to human ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6900103 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Kuang et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alkbh3 Human Ortholog

No data available

Associated With alkbh3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR027450	Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Family	IPR032854	Alkylated DNA repair protein alkB homologue 3
Homologous_superfamily	IPR037151	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Alkylated DNA repair protein alkB homologue 3	Alpha-ketoglutarate-dependent dioxygenase AlkB-like	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily	Oxoglutarate/iron-dependent dioxygenase domain
UniProtKB:F1QRD8	InterPro
UniProtKB:A0A8M2BAA9	InterPro	236

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alkbh3-201 (1) Ensembl	Ensembl	1,475 nt	Select Tool ZFIN BLAST
mRNA	alkbh3-202 (1) Ensembl	Ensembl	1,209 nt	Select Tool ZFIN BLAST
mRNA	alkbh3-203 (1) Ensembl	Ensembl	778 nt	Select Tool ZFIN BLAST
mRNA	alkbh3-204 (1) Ensembl	Ensembl	541 nt	Select Tool ZFIN BLAST
mRNA	alkbh3-205 (1) Ensembl	Ensembl	423 nt	Select Tool ZFIN BLAST
mRNA	alkbh3-206 (1) Ensembl	Ensembl	2,871 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations