Gene
stac3
- ID
- ZDB-GENE-040801-248
- Name
- SH3 and cysteine rich domain 3
- Symbol
- stac3 Nomenclature History
- Previous Names
-
- zgc:91949 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including T-tubule organization; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle contraction. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in adaxial cell; musculature system; and somite. Used to study Native American myopathy. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91949 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-stac3 | N/A | Bower et al., 2012 |
| MO2-stac3 | N/A | (2) |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Native American myopathy | Alliance | Congenital myopathy 13 | 255995 |
1 - 1 of 1
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Native American myopathy | stac3mi34/mi34 | control | Linsley et al., 2017 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | SH3 domain | SH3-like domain superfamily | STAC1/2/3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DBR6 | InterPro | 334 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(actc1b:stac3-EGFP) |
|
| 1 | Linsley et al., 2017 | |
| Tg(acta1a:stac3-EGFP) |
|
| 1 | (2) | |
| Tg(actc1b:stac3-EGFP) |
|
| 1 | Linsley et al., 2017 |
1 - 3 of 3
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11F4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91949 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003505 (1) | 2797 nt | ||
| Genomic | GenBank:CR753874 (1) | 177524 nt | ||
| Polypeptide | UniProtKB:Q6DBR6 (1) | 334 aa |
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Qian, L., Liu, J., Lin, Z., Chen, X., Yuan, L., Shen, G., Yang, W., Wang, D., Huang, Y., Pang, S., Mu, X., Wang, C., Li, Y. (2020) Evaluation of the spinal effects of phthalates in a zebrafish embryo assay. Chemosphere. 249:126144
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Linsley, J.W., Hsu, I.U., Groom, L., Yarotskyy, V., Lavorato, M., Horstick, E.J., Linsley, D., Wang, W., Franzini-Armstrong, C., Dirksen, R.T., Kuwada, J.Y. (2017) Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings of the National Academy of Sciences of the United States of America. 114(2):E228-E236
- Linsley, J.W., Hsu, I.U., Wang, W., Kuwada, J.Y. (2017) Transport of the alpha subunit of the L-type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles. Traffic (Copenhagen, Denmark). 18(9):622-632
- Horstick, E.J., Linsley, J.W., Dowling, J.J., Hauser, M.A., McDonald, K.K., Ashley-Koch, A., Saint-Amant, L., Satish, A., Cui, W.W., Zhou, W., Sprague, S.M., Stamm, D.S., Powell, C.M., Speer, M.C., Franzini-Armstrong, C., Hirata, H., and Kuwada, J.Y. (2013) Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nature communications. 4:1952
- Bower, N.I., Castillo, D.G., Cole, N.J., Hollway, G.E., Lee, H.T., Assinder, S., and Johnston, I.A. (2012) STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle. The Journal of biological chemistry. 287(52):43936-43949
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 8 of 8
Show