Gene

stac3

ID
ZDB-GENE-040801-248
Name
SH3 and cysteine rich domain 3
Symbol
stac3 Nomenclature History
Previous Names
  • zgc:91949 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity. Involved in several processes, including T-tubule organization; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to localize to cytosol; extrinsic component of cytoplasmic side of plasma membrane; and voltage-gated calcium channel complex. Used to study Native American myopathy. Human ortholog(s) of this gene implicated in Native American myopathy. Is expressed in adaxial cell; musculature system; and somite. Orthologous to human STAC3 (SH3 and cysteine rich domain 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stac3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Native American myopathy Alliance Myopathy, congenital, Baily-Bloch 255995
Associated With stac3 Via Experimental Models
Human Disease Fish Conditions Citations
Native American myopathy stac3mi34/mi34 control Linsley et al., 2017
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR035736 Stac3, first SH3 domain
Family IPR039688 STAC1/2/3
Homologous_superfamily IPR036028 SH3-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase C-like, phorbol ester/diacylglycerol-binding domain SH3 domain SH3-like domain superfamily STAC1/2/3 Stac3, first SH3 domain
UniProtKB:A0A0R4IBQ8 207
UniProtKB:Q6DBR6 334
UniProtKB:A0A2R8Q8P0 332
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-stac3 polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations