Gene

ikzf5

ID

ZDB-GENE-040801-209

Name

IKAROS family zinc finger 5

Symbol

ikzf5 Nomenclature History

Previous Names

wu:fb55f09
zgc:92405 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within determination of intestine left/right asymmetry; determination of left/right asymmetry in lateral mesoderm; and determination of pancreatic left/right asymmetry. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; eye; pharyngeal arch cartilage; and thymus. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92405 (1 image)
eu225 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from John et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ikzf5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Thrombocytopenia, autosomal dominant, 7	619130

Associated With ikzf5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050589	Ikaros C2H2-type zinc-finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Ikaros C2H2-type zinc-finger	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:C4XVB6	InterPro	419
UniProtKB:Q6DBW0	InterPro	419

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ikzf5-201 (1) Ensembl	Ensembl	2,560 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-202 (1) Ensembl	Ensembl	2,225 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-203 (1) Ensembl	Ensembl	304 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-204 (1) Ensembl	Ensembl	776 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-205 (1) Ensembl	Ensembl	550 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-206 (1) Ensembl	Ensembl	2,564 nt	Select Tool ZFIN BLAST
mRNA	ikzf5-207 (1) Ensembl	Ensembl	2,986 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations