Gene
med23
- ID
- ZDB-GENE-040724-82
- Name
- mediator complex subunit 23
- Symbol
- med23 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Acts upstream of or within circulatory system development; negative regulation of neurogenesis; and pigmentation. Predicted to be located in nucleus. Predicted to be part of mediator complex and transcription regulator complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14434 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17366 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23624 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36942 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36943 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab398 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 18 | Alliance | Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy | 614249 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR021629 | Mediator complex, subunit Med23 |
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Domain Details Per Protein
| Protein | Length | Mediator complex, subunit Med23 |
|---|---|---|
|
UniProtKB:A0A8M9PSM3
|
1387 | |
|
UniProtKB:A0A8M2B755
|
1380 | |
|
UniProtKB:A0A8M2B7H3
|
1386 | |
|
UniProtKB:Q5RIW8
|
1376 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-med23 | monoclonal | IgG1 , k | Mouse |
|
BD Biosciences
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-272F15 | ||
| Encodes | cDNA | MGC:91979 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003990 (1) | 4668 nt | ||
| Genomic | GenBank:BX072559 (1) | 156196 nt | ||
| Polypeptide | UniProtKB:A0A8M9PSM3 (1) | 1387 aa |
- Xia, M., Chen, K., Yao, X., Xu, Y., Yao, J., Yan, J., Shao, Z., Wang, G. (2017) Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF. Cell Reports. 20:1794-1804
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhu, W., Yao, X., Liang, Y., Liang, D., Song, L., Jing, N., Li, J., Wang, G. (2015) Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling. Development (Cambridge, England). 142(3):465-76
- Yin, J.W., Liang, Y., Park, J.Y., Chen, D., Yao, X., Xiao, Q., Liu, Z., Jiang, B., Fu, Y., Bao, M., Huang, Y., Liu, Y., Yan, J., Zhu, M.S., Yang, Z., Gao, P., Tian, B., Li, D., and Wang, G. (2012) Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes & Development. 26(19):2192-2205
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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