Gene

ptger2b

ID

ZDB-GENE-040724-267

Name

prostaglandin E receptor 2b (subtype EP2)

Symbol

ptger2b Nomenclature History

Previous Names

PRS3 (1)
si:ch211-13n20.1
si:dkey-29m11.3
zgc:136608

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Enables prostaglandin E receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Tsuge et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptger2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma, nasal polyps, and aspirin intolerance	Alliance	{Asthma, aspirin-induced, susceptibility to}	208550

Associated With ptger2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR000370	Prostacyclin (prostanoid IP) receptor
Family	IPR001923	Prostanoid EP2 receptor
Family	IPR008365	Prostanoid receptor