Gene
ptger2b
- ID
- ZDB-GENE-040724-267
- Name
- prostaglandin E receptor 2b (subtype EP2)
- Symbol
- ptger2b Nomenclature History
- Previous Names
-
- PRS3 (1)
- si:ch211-13n20.1
- si:dkey-29m11.3
- zgc:136608
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables prostaglandin E receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tsuge et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asthma, nasal polyps, and aspirin intolerance | Alliance | {Asthma, aspirin-induced, susceptibility to} | 208550 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Prostacyclin (prostanoid IP) receptor | Prostanoid receptor |
|---|---|---|---|---|---|---|
| UniProtKB:Q5RI92 | InterPro | 341 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptger2b-201
(1)
|
Ensembl | 2,330 nt |
Interactions and Pathways
No data available
Plasmids
No data available