ZFIN is now using GRCz12tu for Genomic Data
Gene
lama4
- ID
- ZDB-GENE-040724-213
- Name
- laminin, alpha 4
- Symbol
- lama4 Nomenclature History
- Previous Names
-
- si:busm1-189a20.2
- si:dkey-119m7.3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including endothelial cell development; muscle attachment; and notochord development. Predicted to be located in extracellular region. Is expressed in several structures, including cardiovascular system; head; mesoderm; pectoral fin; and trunk musculature. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7160205 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1JJ | Alliance | Cardiomyopathy, dilated, 1JJ | 615235 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR002049 | Laminin-type EGF domain |
| Domain | IPR009254 | Laminin alpha, domain I |
| Domain | IPR010307 | Laminin domain II |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin alpha, domain I | Laminin domain II | Laminin G domain | Laminin-type EGF domain | Neurexin-related cell adhesion and synaptic protein |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q2TJF5 | InterPro | 1871 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers