Gene
entpd2a.1
- ID
- ZDB-GENE-040724-187
- Name
- ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1
- Symbol
- entpd2a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within response to copper ion and response to ethanol. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; and liver. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000407 | Nucleoside phosphatase GDA1/CD39 |
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Domain Details Per Protein
| Protein | Length | Nucleoside phosphatase GDA1/CD39 |
|---|---|---|
|
UniProtKB:Q66L64
|
502 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
entpd2a.1-201
(1)
|
Ensembl | 3,981 nt | ||
| mRNA |
entpd2a.1-202
(1)
|
Ensembl | 1,359 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-1O1 | ||
| Encodes | cDNA | MGC:101105 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004643 (1) | 4021 nt | ||
| Genomic | GenBank:AL831768 (1) | 149457 nt | ||
| Polypeptide | UniProtKB:Q66L64 (1) | 502 aa |
- Wang, F., Liu, F., Chen, W. (2018) Exposure to triclosan changes the expression of microRNA in male juvenile zebrafish (Danio rerio). Chemosphere. 214:651-658
- Altenhofen, S., Nabinger, D.D., Pereira, T.C.B., Leite, C.E., Bogo, M.R., Bonan, C.D. (2017) Manganese(II) Chloride Alters Nucleotide and Nucleoside Catabolism in Zebrafish (Danio rerio) Adult Brain. Molecular neurobiology. 55(5):3866-3874
- Medrano, M.P., Bejarano, C.A., Battista, A.G., Venera, G.D., Bernabeu, R.O., Faillace, M.P. (2017) Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina. Purinergic signalling. 13(4):443-465
- Zimmermann, F.F., Gaspary, K.V., Siebel, A.M., Leite, C.E., Kist, L.W., Bogo, M.R., Bonan, C.D. (2017) Analysis of Extracellular Nucleotide Metabolism in Adult Zebrafish After Embryological Exposure to Valproic Acid. Molecular neurobiology. 54(5):3542-3553
- Capiotti, K.M., Siebel, A.M., Kist, L.W., Bogo, M.R., Bonan, C.D., Da Silva, R.S. (2016) Hyperglycemia alters E-NTPDases, ecto-5'-nucleotidase, and ectosolic and cytosolic adenosine deaminase activities and expression from encephala of adult zebrafish (Danio rerio). Purinergic signalling. 12(2):211-20
- Soulika, M., Kaushik, A., Mathieu, B., Lourenço, R., Komisarczuk, A.Z., Romano, S.A., Jouary, A., Lardennois, A., Tissot, N., Okada, S., Abe, K., Becker, T.S., Kapsimali, M. (2016) Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs. Development (Cambridge, England). 143(11):2012-24
- Vuaden, F.C., Savio, L.E., Rico, E.P., Mussulini, B.H., Rosemberg, D.B., de Oliveira, D.L., Bogo, M.R., Bonan, C.D., Wyse, A.T. (2016) Methionine Exposure Alters Glutamate Uptake and Adenine Nucleotide Hydrolysis in the Zebrafish Brain. Molecular neurobiology. 53(1):200-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Seibt, K.J., da Luz Oliveira, R., Bogo, M.R., Senger, M.R., Bonan, C.D. (2015) Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain. Fish physiology and biochemistry. 41(6):1383-92
- Gault, W.J., Enyedi, B., Niethammer, P. (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. The Journal of cell biology. 207:767-82
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