Gene
kdm6bb
- ID
- ZDB-GENE-040724-166
- Name
- lysine (K)-specific demethylase 6B, b
- Symbol
- kdm6bb Nomenclature History
- Previous Names
-
- kdm6b
- jmjd3
- jmjd3a (1)
- si:ch211-237l4.7
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables H3K27me3 modified histone binding activity and histone demethylase activity (H3-K27 specific). Involved in histone H3-K27 demethylation and regulation of gene expression. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; fin regeneration; and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in brain; caudal hematopoietic tissue; heart; otic vesicle; and spinal cord. Orthologous to human KDM6B (lysine demethylase 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities | 618505 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | JmjC domain | Lysine-specific demethylase 6, GATA-like domain superfamily |
|---|---|---|---|
|
UniProtKB:A0A8M9QGN3
|
1719 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
kdm6bb-201
(1)
|
5989 nt |
Interactions and Pathways
No data available
Plasmids
No data available