Gene
trpc6a
- ID
- ZDB-GENE-040724-114
- Name
- transient receptor potential cation channel, subfamily C, member 6a
- Symbol
- trpc6a Nomenclature History
- Previous Names
-
- trpc6
- si:rp71-1p14.9
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Is expressed in several structures, including cardiovascular system; gut; integument; keratinocyte; and pectoral fin. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Rolland et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 2 | Alliance | Glomerulosclerosis, focal segmental, 2 | 603965 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6ZM90
|
855 | |||||
|
UniProtKB:F1RCY2
|
874 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpc6a-201
(1)
|
Ensembl | 2,581 nt | ||
| mRNA |
trpc6a-202
(1)
|
Ensembl | 2,706 nt |
Interactions and Pathways
No data available
Plasmids
No data available