Gene

sart3

ID

ZDB-GENE-040724-10

Name

spliceosome associated factor 3, U4/U6 recycling protein

Symbol

sart3 Nomenclature History

Previous Names

earl grey (1)
egy
p110 (1)
si:ch211-191d15.4
unm_sm471
wu:fc51h03

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable U6 snRNA binding activity and histone binding activity. Involved in spliceosomal snRNP assembly. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell homeostasis; and spliceosomal complex assembly. Predicted to be located in Cajal body. Predicted to be part of ASAP complex; U4/U6 snRNP; and U6atac snRNP. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151848 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sart3 Human Ortholog

No data available

Associated With sart3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR008847	Suppressor of forked
Domain	IPR034217	SART3, RNA recognition motif 1
Domain	IPR034218	SART3, RNA recognition motif 2
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Repeat	IPR003107	HAT (Half-A-TPR) repeat