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ZIRC
ZFIN ID: ZDB-GENE-040718-44
Gene Name: R-spondin 1
Gene Symbol: rspo1    Nomenclature History

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Previous Names: cb1071 (1), fj81e05, wu:fj81e05, zgc:92153 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in angiogenesis; hematopoietic stem cell differentiation; and vascular endothelial growth factor receptor signaling pathway. Localizes to the Golgi apparatus and cytosol. Is expressed in several structures, including nervous system; regenerating fin; reproductive system; steroid hormone secreting cell; and tail bud. Orthologous to human RSPO1 (R-spondin 1).
Genome Resources: Alliance (1),  Gene:436625 (1),  Ensembl(GRCz11):ENSDARG00000104340 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012937Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027735Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12606 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16782 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16889 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36198 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42772 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • y135 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rspo1 N/A 1
    MO2-rspo1 N/A 1
    MO3-rspo1 N/A 2
    MO4-rspo1 N/A 1
    DISEASE ASSOCIATED WITH rspo1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Palmoplantar hyperkeratosis and true hermaphroditism 610644
    Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal 610644
    DISEASE ASSOCIATED WITH rspo1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cytosol (more)
    Molecular Function heparin binding (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rspo1-201 (1)    Ensembl 2598
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rspo1 No data available
    MARKER RELATIONSHIPS
    rspo1 Contained in: [BAC] CH211-232M19 (2) (order this)
    rspo1 Encodes: [EST] cb1071 (order this), fj81e05
    [cDNA] MGC:92153 (1) (order this), MGC:173850 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002352 (1) 2517 bp
    Genomic GenBank:BX530064 (1) 153572 bp
    Select Tool
    Polypeptide UniProtKB:A8KBP5 (1) 261 aa
    Sequence Clusters UniGene:161789 (1)
    Sequence Information (all 22)
    ORTHOLOGY for rspo1 ( Chr: 16 )
    CITATIONS (46)