Gene

rspo1

ID
ZDB-GENE-040718-44
Name
R-spondin 1
Symbol
rspo1 Nomenclature History
Previous Names
  • cb1071 (1)
  • fj81e05
  • wu:fj81e05
  • zgc:92153 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have heparin binding activity. Involved in angiogenesis; hematopoietic stem cell differentiation; and vascular endothelial growth factor receptor signaling pathway. Localizes to Golgi apparatus and cytosol. Is expressed in several structures, including nervous system; regenerating fin; reproductive system; steroid hormone secreting cell; and tail bud. Orthologous to human RSPO1 (R-spondin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rspo1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Palmoplantar hyperkeratosis and true hermaphroditism 610644
Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal 610644
Associated With rspo1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR043601 R-spondin, Fu-CRD domain
Family IPR042991 R-spondin-1
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like repeat Growth factor receptor cysteine-rich domain superfamily R-spondin-1 R-spondin, Fu-CRD domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:M5AP50 261
UniProtKB:Q6DHR0 261
UniProtKB:A8KBP5 261
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations