Gene

ap4m1

ID

ZDB-GENE-040718-421

Name

adaptor related protein complex 4 subunit mu 1

Symbol

ap4m1 Nomenclature History

Previous Names

si:ch211-237l4.1
zgc:91931 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to be involved in Golgi to lysosome transport and protein targeting. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91931 (1 image)
IMAGE:7161708 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ap4m1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 50	Alliance	Spastic paraplegia 50, autosomal recessive	612936

Associated With ap4m1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022775	AP complex, mu/sigma subunit
Domain	IPR028565	Mu homology domain
Family	IPR001392	Clathrin adaptor, mu subunit
Family	IPR050431	Adaptor complexes medium subunit
Homologous_superfamily	IPR011012	Longin-like domain superfamily
Homologous_superfamily	IPR036168	AP-2 complex subunit mu, C-terminal superfamily