Gene
rnaseh1
- ID
- ZDB-GENE-040718-407
- Name
- ribonuclease H1
- Symbol
- rnaseh1 Nomenclature History
- Previous Names
-
- zgc:91971
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rnaseh1 | (2) | |
| CRISPR2-rnaseh1 | Thomas et al., 2024 | |
| MO1-rnaseh1 | N/A | Xu et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2 | Alliance | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 | 616479 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Large ribosomal subunit protein bL9/RNase H1, N-terminal | Ribonuclease H | Ribonuclease H1, eukaryote | Ribonuclease H1, N-terminal | Ribonuclease H1, N-terminal domain superfamily | Ribonuclease H domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N0V4 | InterPro | 297 | ||||||||
| UniProtKB:Q6DG94 | InterPro | 276 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnaseh1-201
(1)
|
Ensembl | 1,281 nt | ||
| mRNA |
rnaseh1-202
(1)
|
Ensembl | 835 nt | ||
| mRNA |
rnaseh1-204
(1)
|
Ensembl | 1,117 nt | ||
| ncRNA |
rnaseh1-003
(1)
|
Ensembl | 535 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284K10 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-7F8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7156473 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:91971 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191800 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002659 (1) | 1324 nt | ||
| Genomic | GenBank:BX293564 | 145495 nt | ||
| Polypeptide | UniProtKB:A0A8M1N0V4 (1) | 297 aa |
- Thomas, R.C., Zaksauskaite, R., Al-Kandari, N.Y., Hyde, A.C., Abugable, A.A., El-Khamisy, S.F., van Eeden, F.J. (2024) Second generation lethality in RNAseH2a knockout zebrafish. Nucleic acids research. 52(18):11014-11028
- Xu, W., Liu, X., Li, J., Sun, C., Chen, L., Zhou, J., Li, K., Li, Q., Meng, A., Sun, Q. (2024) ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis. Cell insight. 3:100179100179
- Raman, R., Ryon, M., Jagadeeswaran, P. (2020) RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Scientific Reports. 10:20187
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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