Gene
slc2a3a
- ID
- ZDB-GENE-040718-390
- Name
- solute carrier family 2 member 3a
- Symbol
- slc2a3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable D-glucose transmembrane transporter activity. Acts upstream of or within brain development. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and spinal cord neural tube. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-slc2a3a | N/A | (3) |
| MO2-slc2a3a | N/A | (3) |
| MO3-slc2a3a | N/A | Carayannopoulos et al., 2014 |
| MO4-slc2a3a | N/A | Carayannopoulos et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glucose transporter GLUT | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B5Y7
|
575 | ||||||
|
UniProtKB:Q6DFZ5
|
541 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a3a-201
(1)
|
Ensembl | 3,800 nt | ||
| mRNA |
slc2a3a-202
(1)
|
Ensembl | 3,968 nt | ||
| mRNA |
slc2a3a-203
(1)
|
Ensembl | 1,923 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14O18 | ZFIN Curated Data | |
| Encodes | EST | fb92c06 | ||
| Encodes | cDNA | MGC:92476 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002643 (1) | 3765 nt | ||
| Genomic | GenBank:BX927218 (2) | 208809 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5Y7 (1) | 575 aa |
- Gaitán-Peñas, H., Pérez-Rius, C., Muhaisen, A., Castellanos, A., Errasti-Murugarren, E., Barrallo-Gimeno, A., Alcaraz-Pérez, F., Estévez, R. (2024) Characterization of ClC-1 chloride channels in zebrafish: a new model to study myotonia. The Journal of physiology. 602(16):3975-3994
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257
- Md Razip, N.N., Mohd Noor, S., Norazit, A., Nordin, N., Sakeh, N.M., Khaza'ai, H. (2022) An Association between Insulin Resistance and Neurodegeneration in Zebrafish Larval Model (Danio rerio). International Journal of Molecular Sciences. 23(15)
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Kang, T., Zhao, S., Shi, L., Li, J. (2021) Glucose metabolism is required for oocyte maturation of zebrafish. Biochemical and Biophysical Research Communications. 559:191-196
- Dos Santos, M.M., de Macedo, G.T., Prestes, A.S., Ecker, A., Müller, T.E., Leitemperger, J., Fontana, B.D., Ardisson-Araújo, D.M.P., Rosemberg, D.B., Barbosa, N.V. (2020) Modulation of Redox and insulin signaling underlie the anti-hyperglycemic and antioxidant effects of diphenyl diselenide in zebrafish. Free radical biology & medicine. 158:20-31
- Yin, H.M., Yan, L.F., Liu, Q., Peng, Z., Zhang, C.Y., Xia, Y., Su, D., Gu, A.H., Zhou, Y. (2020) Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science advances. 6:eaay9466
- Lechermeier, C.G., Zimmer, F., Lüffe, T.M., Lesch, K.P., Romanos, M., Lillesaar, C., Drepper, C. (2019) Transcript Analysis of Zebrafish GLUT3 Genes, slc2a3a and slc2a3b, Define Overlapping as Well as Distinct Expression Domains in the Zebrafish (Danio rerio) Central Nervous System. Frontiers in molecular neuroscience. 12:199
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