Gene
acss2
- ID
- ZDB-GENE-040718-388
- Name
- acyl-CoA synthetase short chain family member 2
- Symbol
- acss2 Nomenclature History
- Previous Names
-
- fa04c03
- fj80b06
- fj80h04
- wu:fa04c03
- wu:fj80b06
- wu:fj80h04
- zgc:92200
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable acetate-CoA ligase activity. Predicted to be involved in acetyl-CoA biosynthetic process. Predicted to act upstream of or within acetyl-CoA biosynthetic process from acetate and lipid metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tilghman et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020845 | AMP-binding, conserved site |
| Domain | IPR000873 | AMP-dependent synthetase/ligase domain |
| Domain | IPR025110 | AMP-binding enzyme, C-terminal domain |
| Domain | IPR032387 | Acetyl-coenzyme A synthetase, N-terminal domain |
| Family | IPR011904 | Acetate-CoA ligase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acetate-CoA ligase | Acetyl-coenzyme A synthetase, N-terminal domain | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q6G5 | InterPro | 682 | |||||||
| UniProtKB:F1QAA7 | InterPro | 698 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-268E11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-66G10 | ZFIN Curated Data | |
| Encodes | EST | fa04c03 | ||
| Encodes | EST | fj80b06 | ||
| Encodes | EST | fj80h04 | ||
| Encodes | cDNA | MGC:92200 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328353 (1) | 3858 nt | ||
| Genomic | GenBank:CT027560 (1) | 81113 nt | ||
| Polypeptide | UniProtKB:F1QAA7 (1) | 698 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ACSS2 | 20 | Amino acid sequence comparison (1) |
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Tilghman, J.M., Ling, A.Y., Turner, T.N., Sosa, M.X., Krumm, N., Chatterjee, S., Kapoor, A., Coe, B.P., Nguyen, K.H., Gupta, N., Gabriel, S., Eichler, E.E., Berrios, C., Chakravarti, A. (2019) Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. The New England Journal of Medicine. 380:1421-1432
- Watkins, P.A., Maiguel, D., Jia, Z., and Pevsner, J. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Journal of Lipid Research. 48(12):2736-2750
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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