Gene

supt3h

ID

ZDB-GENE-040718-370

Name

SPT3 homolog, SAGA and STAGA complex component

Symbol

supt3h Nomenclature History

Previous Names

zgc:92246

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable transcription coactivator activity. Predicted to act upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909219 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen
sa2918	Allele with one point mutation	Unknown	Splice Site	ENU
sa4690	Allele with one point mutation	Unknown	Premature Stop	ENU
sa5628	Allele with one point mutation	Unknown	Splice Site	ENU

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Sequence Targeting Reagents

No data available

Human Disease

Associated With supt3h Human Ortholog

No data available

Associated With supt3h Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR003195	Transcription initiation factor IID, subunit 13
Homologous_superfamily	IPR009072	Histone-fold

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Domain Details Per Protein

Protein	Length	Histone-fold	Transcription initiation factor IID, subunit 13
UniProtKB:Q6DHL1 InterPro	371
UniProtKB:A0A0R4IR35 InterPro	380

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	supt3h-201 (1) Ensembl	Ensembl	1,461 nt	Select Tool ZFIN BLAST
mRNA	supt3h-203 (1) Ensembl	Ensembl	566 nt	Select Tool ZFIN BLAST
mRNA	supt3h-204 (1) Ensembl	Ensembl	638 nt	Select Tool ZFIN BLAST
mRNA	supt3h-205 (1) Ensembl	Ensembl	4,980 nt	Select Tool ZFIN BLAST
ncRNA	supt3h-003 (1) Ensembl	Ensembl	387 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-42B22	BX510331	ZFIN Curated Data
Contained in	BAC	CH211-253F14	AL772396	ZFIN Curated Data
Encodes	EST	IMAGE:6909219	CB365449	Thisse et al., 2004
Encodes	cDNA	MGC:92246	BC075959	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001002625 (1)	1605 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX510331 (1)	150762 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IR35 (1)	380 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	SUPT3H	6	Ensembl:ENSG00000196284 Gene:8464 OMIM:602947 HGNC:11466	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Supt3	17	Ensembl:ENSMUSG00000038954 MGI:1923723 Gene:109115	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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