nme5

ID

ZDB-GENE-040718-221

Name

NME/NM23 family member 5

Symbol

nme5 Nomenclature History

Previous Names

NM23-Z5 (1)
zgc:92812

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable 3'-5' exonuclease activity. Involved in cilium movement. Predicted to be located in cell projection. Predicted to be active in cilium. Is expressed in Kupffer's vesicle; forerunner cell group; male organism; nervous system; and pleuroperitoneal region. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92812 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Cho et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nme5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Ciliary dyskinesia, primary, 48, without situs inversus	620032

Associated With nme5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
primary ciliary dyskinesia	AB + MO1-nme5	standard conditions	Cho et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR007858	Dpy-30 motif
Domain	IPR034907	Nucleoside diphosphate kinase-like domain
Family	IPR001564	Nucleoside diphosphate kinase
Homologous_superfamily	IPR036397	Ribonuclease H superfamily
Homologous_superfamily	IPR036850	Nucleoside diphosphate kinase-like domain superfamily