kpna2

ID

ZDB-GENE-040718-22

Name

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Symbol

kpna2 Nomenclature History

Previous Names

hm:zeh0389
hm:zeh0389r
zeh0389
zeh0389r
zgc:113902
zgc:86945 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytosol; host cell; and nucleoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human KPNA2 (karyopherin subunit alpha 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147301 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kpna2 Human Ortholog

No data available

Associated With kpna2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002652	Importin-alpha, importin-beta-binding domain
Family	IPR024931	Importin subunit alpha
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036975	Importin-alpha, importin-beta-binding domain superfamily
Repeat	IPR000225	Armadillo
Repeat	IPR032413	Atypical Arm repeat