Gene
dusp22a
- ID
- ZDB-GENE-040718-219
- Name
- dual specificity phosphatase 22a
- Symbol
- dusp22a Nomenclature History
- Previous Names
-
- dusp22
- wu:fa11e09
- zgc:92816
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to several human genes including DUSP15 (dual specificity phosphatase 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146559 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32212 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dusp22a | Uribe-Salazar et al., 2022 | |
| CRISPR2-dusp22a | Uribe-Salazar et al., 2022 | |
| CRISPR3-dusp22a | Uribe-Salazar et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LWL2 | InterPro | 208 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dusp22a-201
(1)
|
Ensembl | 1,308 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-265O13 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-77B5 | ZFIN Curated Data | |
| Encodes | EST | fa11e09 | ||
| Encodes | EST | IMAGE:7146559 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92816 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002514 (1) | 1321 nt | ||
| Genomic | GenBank:BX548023 (1) | 151449 nt | ||
| Polypeptide | UniProtKB:Q1LWL2 (1) | 208 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | DUSP22 | 6 | Amino acid sequence comparison (1) |
- Uribe-Salazar, J.M., Kaya, G., Sekar, A., Weyenberg, K., Ingamells, C., Dennis, M.Y. (2022) Evaluation of CRISPR gene-editing tools in zebrafish. BMC Genomics. 23:12
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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