Gene
syt1a
- ID
- ZDB-GENE-040718-165
- Name
- synaptotagmin Ia
- Symbol
- syt1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to be located in chromaffin granule membrane and synapse. Predicted to be active in axon; plasma membrane; and secretory vesicle. Is expressed in brain and visual system. Orthologous to human SYT1 (synaptotagmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92899 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Baker-Gordon syndrome | 618218 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Synaptotagmin |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BC44 | InterPro | 416 | |||
| UniProtKB:Q5TZ27 | InterPro | 419 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-277M17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-210E13 | ZFIN Curated Data | |
| Encodes | EST | fj41c01 | ZFIN Curated Data | |
| Encodes | EST | fk56d05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92899 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191919 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327829 (1) | 5150 nt | ||
| Genomic | GenBank:BX511172 (1) | 249278 nt | ||
| Polypeptide | UniProtKB:Q5TZ27 (1) | 419 aa |
- Shiao, M.S., Liu, S.T., Siriwatcharapibool, G., Thongpradit, S., Khunpanich, P., Tong, S.K., Huang, C.H., Jinawath, N., Chou, M.Y. (2024) Conserved expression of the zebrafish syt4 gene in GABAergic neurons in the cerebellum of adult fishes revealed by mammalian SYT4 immunoreactive-like signals. Heliyon. 10:e30575e30575
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Haridevamuthu, B., Manjunathan, T., Guru, A., Ranjith Wilson Alphonse, C., Boopathi, S., Murugan, R., Gatasheh, M.K., Atef Hatamleh, A., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Brain research. 1788:147941
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Faria, M., Prats, E., Rosas Ramírez, J.R., Bellot, M., Bedrossiantz, J., Pagano, M., Valls, A., Gomez-Canela, C., Porta, J.M., Mestres, J., Garcia-Reyero, N., Faggio, C., Gómez Oliván, L.M., Raldua, D. (2021) Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion. The Science of the total environment. 775:145671
- Henry, D., Joselevitch, C., Matthews, G.G., Wollmuth, L.P. (2021) Expression and distribution of synaptotagmin family members in the zebrafish retina. The Journal of comparative neurology. 530(4):705-728
- Dubińska-Magiera, M., Niedbalska-Tarnowska, J., Migocka-Patrzałek, M., Posyniak, E., Daczewska, M. (2020) Characterization of Hspb8 in Zebrafish. Cells. 9(6):
- Faria, M., Ziv, T., Gómez-Canela, C., Ben-Lulu, S., Prats, E., Novoa-Luna, K.A., Admon, A., Piña, B., Tauler, R., Gómez-Oliván, L.M., Raldúa, D. (2018) Acrylamide acute neurotoxicity in adult zebrafish. Scientific Reports. 8:7918
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Prats, E., Gómez-Canela, C., Ben-Lulu, S., Ziv, T., Padrós, F., Tornero, D., Garcia-Reyero, N., Tauler, R., Admon, A., Raldúa, D. (2017) Modelling acrylamide acute neurotoxicity in zebrafish larvae. Scientific Reports. 7:13952
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