Gene
agxta
- ID
- ZDB-GENE-040718-16
- Name
- alanine--glyoxylate and serine--pyruvate aminotransferase a
- Symbol
- agxta Nomenclature History
- Previous Names
-
- agxtl
- zgc:91879
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have alanine-glyoxylate transaminase activity and serine-pyruvate transaminase activity. Predicted to be involved in glycine biosynthetic process, by transamination of glyoxylate. Predicted to localize to peroxisome. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Is expressed in liver and pronephric duct. Orthologous to human AGXT (alanine--glyoxylate and serine--pyruvate aminotransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91879 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hyperoxaluria type 1 | Alliance | Hyperoxaluria, primary, type 1 | 259900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR020578 | Aminotransferase class-V, pyridoxal-phosphate binding site |
| Domain | IPR000192 | Aminotransferase class V domain |
| Family | IPR024169 | Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Aminotransferase class V domain | Aminotransferase class-V, pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DG86
|
391 |
Interactions and Pathways
No data available
Plasmids
No data available