Gene
dgat1b
- ID
- ZDB-GENE-040718-158
- Name
- diacylglycerol O-acyltransferase 1b
- Symbol
- dgat1b Nomenclature History
- Previous Names
-
- DGAT1A (1)
- zgc:92327
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within response to yeast. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027725Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2838 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39109 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42756 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dgat1b | Lumaquin-Yin et al., 2023 | |
| CRISPR2-dgat1b | Lumaquin-Yin et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital diarrhea 7 with exudative enteropathy | Alliance | Diarrhea 7, protein-losing enteropathy type | 615863 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Diacylglycerol O-acyltransferase 1 | Membrane bound O-acyl transferase, MBOAT | Sterol O-acyltransferase, ACAT/DAG/ARE types |
|---|---|---|---|---|
|
UniProtKB:A0A8M9NZ90
|
411 | |||
|
UniProtKB:Q6DHG2
|
507 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dgat1b-201
(1)
|
Ensembl | 2,753 nt | ||
| mRNA |
dgat1b-202
(1)
|
Ensembl | 849 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198D13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92327 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002458 (1) | 2780 nt | ||
| Genomic | GenBank:BX510336 (1) | 169172 nt | ||
| Polypeptide | UniProtKB:Q6DHG2 (1) | 507 aa |
- Lumaquin-Yin, D., Montal, E., Johns, E., Baggiolini, A., Huang, T.H., Ma, Y., LaPlante, C., Suresh, S., Studer, L., White, R.M. (2023) Lipid droplets are a metabolic vulnerability in melanoma. Nature communications. 14:31923192
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Sun, S., Cao, X., Castro, L.F.C., Monroig, Ó., Gao, J. (2021) A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity. Functional & integrative genomics. 21(5-6):557-570
- Xu, H., Jiang, Y., Miao, X.M., Tao, Y.X., Xie, L., Li, Y. (2021) A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. Biology. 10(2):
- Li, D.L., Huang, Y.J., Gao, S., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2019) Sex-specific alterations of lipid metabolism in zebrafish exposed to polychlorinated biphenyls. Chemosphere. 221:768-777
- Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. (2019) Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Chemosphere. 232:171-179
- Sæle, Ø., Rød, K.E.L., Quinlivan, V.H., Li, S., Farber, S.A. (2018) A novel system to quantify intestinal lipid digestion and transport. Biochimica et biophysica acta. 1863(9):948-957
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Qi, S., Liu, W., Zheng, Y. (2018) Thifluzamide affects lipid metabolism in zebrafish (Danio reio). The Science of the total environment. 633:1227-1236
- Yao, Y., Sun, S., Wang, J., Fei, F., Dong, Z., Ke, A.W., He, R., Wang, L., Zhang, L., Ji, M.B., Li, Q., Yu, M., Shi, G.M., Fan, J., Gong, Z., Wang, X. (2018) Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult. Cancer research. 78(19):5548-5560
- Cui, Y., Lv, S., Liu, J., Nie, S., Chen, J., Dong, Q., Huang, C., Yang, D. (2017) Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Human & Experimental Toxicology. 36(3):207-217
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