Gene

six1a

ID
ZDB-GENE-040718-155
Name
SIX homeobox 1a
Symbol
six1a Nomenclature History
Previous Names
  • six1b (1)
  • six2
  • zgc:92332 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of inner ear receptor cell differentiation; regulation of skeletal muscle cell proliferation; and skeletal muscle fiber development. Predicted to localize to nucleus and transcription regulator complex. Is expressed in musculature system; nervous system; otic vesicle; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With six1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 23 Alliance Deafness, autosomal dominant 23 605192
branchiootic syndrome Alliance Branchiootic syndrome 3 608389
Associated With six1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Family IPR031278 Homeobox protein SIX1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Homeobox protein SIX1 Homeobox protein SIX1, N-terminal SD domain
UniProtKB:Q6DHF9 283
UniProtKB:Q9W7H4 63
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations