Gene

six1a

ID

ZDB-GENE-040718-155

Name

SIX homeobox 1a

Symbol

six1a Nomenclature History

Previous Names

six1b (1)
six2
zgc:92332 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including regulation of inner ear receptor cell differentiation; regulation of skeletal muscle cell proliferation; and skeletal muscle fiber development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anterior migratory muscle precursor stream; middle migratory muscle precursor stream; musculature system; nervous system; and posterior migratory muscle precursor stream. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7154851 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With six1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 23	Alliance	Deafness, autosomal dominant 23	605192
branchiootic syndrome	Alliance	Branchiootic syndrome 3	608389

Associated With six1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR031701	Homeobox protein SIX1, N-terminal SD domain
Family	IPR031278	Homeobox protein SIX1
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily