Gene
six1a
- ID
- ZDB-GENE-040718-155
- Name
- SIX homeobox 1a
- Symbol
- six1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of inner ear receptor cell differentiation; regulation of skeletal muscle cell proliferation; and skeletal muscle fiber development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anterior migratory muscle precursor stream; middle migratory muscle precursor stream; musculature system; nervous system; and posterior migratory muscle precursor stream. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154851 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 23 | Alliance | Deafness, autosomal dominant 23 | 605192 |
| branchiootic syndrome | Alliance | Branchiootic syndrome 3 | 608389 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein SIX1, N-terminal SD domain | Homeodomain | KN homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QFC5 | InterPro | 283 | |||||
| UniProtKB:Q6DHF9 | InterPro | 283 |
Interactions and Pathways
No data available
Plasmids
No data available