ZFIN is now using GRCz12tu for Genomic Data
Gene
sbf1
- ID
- ZDB-GENE-040718-139
- Name
- SET binding factor 1
- Symbol
- sbf1 Nomenclature History
- Previous Names
-
- wu:fj45d12
- zgc:92634 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within myelination of posterior lateral line nerve axons and regulation of axonogenesis. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B3. Orthologous to human SBF1 (SET binding factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92634 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Lindzon et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 4B3 | Alliance | Charcot-Marie-Tooth disease, type 4B3 | 615284 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 4B3 | sbf1hsc231/hsc231 (AB) | standard conditions | Lindzon et al., 2025 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001194 | cDENN domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR004182 | GRAM domain |
| Domain | IPR005112 | dDENN domain |
| Domain | IPR005113 | uDENN domain |
| Domain | IPR010569 | Myotubularin-like, phosphatase domain |
| Domain | IPR022096 | SBF1/SBF2 domain |
| Domain | IPR037516 | Tripartite DENN domain |
| Family | IPR051696 | DENN Domain-Containing GEFs |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR043153 | DENN domain, C-terminal lobe |
Domain Details Per Protein
| Protein | Additional Resources | Length | cDENN domain | dDENN domain | DENN Domain-Containing GEFs | DENN domain, C-terminal lobe | GRAM domain | Myotubularin-like, phosphatase domain | PH-like domain superfamily | Pleckstrin homology domain | Protein-tyrosine phosphatase-like | SBF1/SBF2 domain | Tripartite DENN domain | uDENN domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ARB7 | InterPro | 1926 | ||||||||||||
| UniProtKB:A0A2R8PWA9 | InterPro | 1936 | ||||||||||||
| UniProtKB:A0A8M2BBQ3 | InterPro | 1918 | ||||||||||||
| UniProtKB:F1QFF3 | InterPro | 1883 | ||||||||||||
| UniProtKB:A0A8M2BBZ8 | InterPro | 1908 | ||||||||||||
| UniProtKB:A0A8M3B8V9 | InterPro | 1911 | ||||||||||||
| UniProtKB:Q1LXZ0 | InterPro | 1849 | ||||||||||||
| UniProtKB:A0AB32TKA8 | InterPro | 1893 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers