Gene
entpd4
- ID
- ZDB-GENE-040718-116
- Name
- ectonucleoside triphosphate diphosphohydrolase 4
- Symbol
- entpd4 Nomenclature History
- Previous Names
-
- NTPDase4 (1)
- wu:fd44h12
- wu:fi73e02
- zgc:92668
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in CTP metabolic process and UDP catabolic process. Predicted to be active in Golgi apparatus and membrane. Is expressed in brain; female organism; heart; and liver. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92668 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6105 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31685 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34502 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34503 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000407 | Nucleoside phosphatase GDA1/CD39 |
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Domain Details Per Protein
| Protein | Length | Nucleoside phosphatase GDA1/CD39 |
|---|---|---|
|
UniProtKB:A0A8M2BEM8
|
619 | |
|
UniProtKB:A0A8M9Q3E6
|
615 | |
|
UniProtKB:Q6DH30
|
611 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
entpd4-201
(1)
|
Ensembl | 2,673 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-132K15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-200G12 | ZFIN Curated Data | |
| Encodes | EST | fd44h12 | ||
| Encodes | EST | fi73e02 | ||
| Encodes | cDNA | MGC:92668 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002419 (1) | 2696 nt | ||
| Genomic | GenBank:CU929411 (2) | 106947 nt | ||
| Polypeptide | UniProtKB:A0A8M2BEM8 (1) | 619 aa |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Hugo, S.E., Schlegel, A. (2017) A genetic model to study increased hexosamine biosynthetic flux. Endocrinology. 158(8):2420-2426
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Rosemberg, D.B., Rico, E.P., Langoni, A.S., Spinelli, J.T., Pereira, T.C., Dias, R.D., Souza, D.O., Bonan, C.D., and Bogo, M.R. (2010) NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 155(3):230-240
- Levi, L., Pekarski, I., Gutman, E., Fortina, P., Hyslop, T., Biran, J., Levavi-Sivan, B., and Lubzens, E. (2009) Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. BMC Genomics. 10:141
- O'Boyle, S., Bree, R.T., McLoughlin, S., Grealy, M., and Byrnes, L. (2007) Identification of zygotic genes expressed at the midblastula transition in zebrafish. Biochemical and Biophysical Research Communications. 358(2):462-468
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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